Fig. 8: Summary model of the MAPK-activated regulator FTZ-F1 maintaining a growth-defense balance with enhanced tolerance/resistance of P. xylostella to Bt Cry1Ac toxin. | Nature Communications

Fig. 8: Summary model of the MAPK-activated regulator FTZ-F1 maintaining a growth-defense balance with enhanced tolerance/resistance of P. xylostella to Bt Cry1Ac toxin.

From: A single transcription factor facilitates an insect host combating Bacillus thuringiensis infection while maintaining fitness

Fig. 8

Phosphorylated FTZ-F1 activates non-receptor genes via the motif “TAMAGTC”, while non-phosphorylated FTZ-F1 induces receptor genes via the binding site “YCAAGGYCR”. The activated MAPK cascade elevates the phosphorylation level of FTZ-F1, reducing the pool of non-phosphorylated TF, leading to upregulation of non-receptor gene expression and downregulation of receptor gene expression, which confers tolerance/resistance of P. xylostella to Cry1Ac toxin without growth penalty. Degenerate bases: M(A/C); Y(C/T); R(A/G).

Back to article page