Fig. 6: DBP and E2F8 play opposite roles of Th9 cell mediated anti-tumor activity in vivo. | Nature Communications

Fig. 6: DBP and E2F8 play opposite roles of Th9 cell mediated anti-tumor activity in vivo.

From: Opposing functions of circadian protein DBP and atypical E2F family E2F8 in anti-tumor Th9 cell differentiation

Fig. 6

a Intracellular staining of IL-9 produced by CD4+ T cells with indicated shRNA transfection before cells were transferred into Rag1−/− mice. Tumor growth over time in 8-week-old male and female Rag1−/− mice given intravenous transfer of CTRL, Dbp or E2f8 shRNA treated CD4+ T cells along with simultaneous subcutaneous injection of b B16 melanoma cells (male: n = 5 and female: n = 3 mice per group) or d MCA205 fibrosarcoma cells (male: n = 5 and female: n = 5 mice per group) on day 0. c, e Tumor weight at the end of experiments from b and d. These data were analyzed by two-tailed unpaired Student’s t-test. These data were representative of two independent experiments. Graphs show the mean±SEM. Source data are provided as a Source Data file.

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