Fig. 1: Chemical evolution of DDD2049209 (8) from the initial hit 1.
From: Lysyl-tRNA synthetase, a target for urgently needed M. tuberculosis drugs
Potencies are shown against: in vitro enzymes LysRS & KARS1; M. tuberculosis phenotypic growth in culture (MIC), M. tuberculosis growth within macrophages, and cytotoxicity against human HepG2 cells. Data shown are the geometric mean of at least two independent replicates. Source data are provided as a Source Data file.
