Fig. 9: Enhanced differentiation from TRM stem to non-TRM stem in TDLN and accumulation of migratory effectors in tumor for Tgfbr2−/− Pmel-1 T cells.
From: TGF-β-dependent lymphoid tissue residency of stem-like T cells limits response to tumor vaccine
Bulk RNA-seq was performed on sorted Pmel-1 T cells isolated from TDLN and tumor. GSEA (gene set enrichment analysis) results are shown. Red, WT and violet, Tgfbr2−/−. a Core TRM signature enrichment in TDLN samples. b The signatures of exhuasted CD8+ subsets in TDLN samples. Published differentiation pathway is illustrated in bottom panel. c Core TRM signature enrichment in tumor samples. d The signatures of exhuasted CD8+ subsets in tumor samples. e Heatmap of differentially expressed signature genes. All groups contain biological independent duplicates.
