Fig. 5: Quantitative analysis of intercellular communication between CARMz T and CARP T cells. | Nature Communications

Fig. 5: Quantitative analysis of intercellular communication between CARMz T and CARP T cells.

From: Co-expression of a PD-L1-specific chimeric switch receptor augments the efficacy and persistence of CAR T cells via the CD70-CD27 axis

Fig. 5

a, b The inferred interaction strength of CD4+ central memory CARMz T cells (M-Tcm4) and CD8+ central memory CARMz T cells (M-Tcm8) with other cell clusters from CARMz T and CARP T cells. The top three interaction strength were shown with numbers that indicate the strength of interactions in Supplementary TableΒ 1. c Heatmap shows the inferred incoming signaling pathways of M-Tcm4 and M-Tcm8 and outgoing signaling pathways of P-Tef8 and P-Tua8 by CellChat tool. Incoming signaling pathways are shown in the red box on the left and outgoing signaling pathways are shown in the blue box on the right. The relative strength was used to calculate intercellular communication probability. β€œM” indicates CARMz T and β€œP” indicates CARP T cells as for the name of each cell cluster on the horizontal axis. d Dot plot shows the average expression of CD27 and CD70 in M-Tcm4, M-Tcm8, and P-Tef8 clusters.

Back to article page