Fig. 3: Disease-associated cytokines associate with C4A protein levels in cerebrospinal fluid of patients with first-episode psychosis. | Nature Communications

Fig. 3: Disease-associated cytokines associate with C4A protein levels in cerebrospinal fluid of patients with first-episode psychosis.

From: Cerebrospinal fluid concentration of complement component 4A is increased in first episode schizophrenia

Fig. 3

a Overview of cytokine analyses. Cerebrospinal fluid (CSF) from patients with first-episode psychosis in the KaSP cohort (n = 26) were analyzed for interleukin (IL)−1beta, IL-6, and C4A levels. Median age in the cohort was 29 years (interquartile range: 23-32) and 18 participants were males. b CSF C4A protein levels (adjusted for genetically predicted C4A RNA expression) correlated with IL-1beta levels (r = 0.39; 95% confidence interval [CI]: 0.01–0.68, P = 0.046), c but not IL-6 levels (r = −0.05 CI: −0.44–0.36, P = 0.820). c C4B protein levels (adjusted for genetically predicted C4B RNA expression) did not correlate significantly with IL-1beta levels (r = 0.29 CI: −0.12–0.62, P = 0.150; c), or d IL6 levels (r = 0.32 CI: −0.09–0.64, P = 0.112). Data were analyzed by creating CSF C4A (or C4B) levels adjusted for predicted RNA expression (by extracting unstandardized residuals from a linear regression model analyzing predicted RNA expression vs. measured CSF protein levels), and then used in Spearman correlation analyses against CSF cytokine levels. All reported P values are two sided. Intercepts and 95% CI bands are indicated in figure panel 3b–d. Source data for graphs in figure panels 3b–e are provided in the Source Data file. Figure 3a was created with BioRender.com.

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