Fig. 2: Severity of illness scores in patients infected with variant Delta (red; n = 111) and variant Omicron (blue; n = 148).

a SAPS II scores at ICU admission; b SOFA score at day 0 (admission at the ICU) and day 3 of hospitalization (by two-way ANOVA, there was a significant effect of the variant (p = 0.0269), no significant effect of time (p = 0.2784), and no significant interaction of both parameters (variant x time; p = 0.7668)). In (a) and (b), data distribution is represented using violin plots and horizontal bars show the median and quartiles 25 and 75; c Organ system components of the SOFA score at ICU admission. Data distribution is represented using box-and-whisker plots, displaying median values and quartiles 25 and 75 (i.e., lower and upper limits of the box), and 5 and 95% percentiles (circles). Two-sided p-values have been generated with the Mann–Whitney test or the Sidak post-hoc ANOVA test; n = 111 and 148 independent measurements in the Delta and Omicron groups, respectively. SOFA: Sequential Organ Failure Assessment; SAPS II: Simplified Acute Physiology Score II; Source data are provided as a Source Data file.