Fig. 4: Relationship between SARS-CoV-2 mutations/deletions and day-28 mortality in patients infected with variant Omicron. | Nature Communications

Fig. 4: Relationship between SARS-CoV-2 mutations/deletions and day-28 mortality in patients infected with variant Omicron.

From: Clinical phenotypes and outcomes associated with SARS-CoV-2 variant Omicron in critically ill French patients with COVID-19

Fig. 4

Over the full-length viral genomes of 97 Omicron sample-related patients, we investigated amino acid modifications (substitutions or deletions) outside Spike protein found in at least 20 viral genomes of patients infected by Omicron (n = 11 positions) and analyzed the relationship between these mutations and day-28 mortality in univariable analysis. Two amino acid substitutions (ORF1a-K856R = NSP3 K38R and M-D3G) were significantly associated with day-28 mortality but this relationship was no longer significant after correction of p-values for test multiplicity using the Benjamini–Hochberg procedure. Day 28 mortality is displayed in red and day 28 survival in blue; p-values come from unadjusted logistic regression modeling. Horizontal bars represent percentages; Source data are provided as a Source Data file.

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