Fig. 1: Strategy for the development of macrocyclic peptides against the Lys63-linked Ub chain.
From: Selective macrocyclic peptide modulators of Lys63-linked ubiquitin chains disrupt DNA damage repair
a The general discovery process for macrocyclic peptides for Di-Ub chains using chemical protein synthesis and RaPID approach to affect specific biological functions. b Schematic presentation of RaPID method for the identification of potent binder 1 (CP1) for Lys63-linked Di-Ub.
