Fig. 5: Three-dimensional visualisation of brain sulcal associations (Z-scores) for four exemplar pleiotropic loci.
From: Genetic map of regional sulcal morphology in the human brain from UK biobank data
An interactive online tool, available at https://enigma-brain.org/sulci-browser, was used to visualise genetic influences on sulcal morphology in three dimensions, revealing (a) widespread, positive associations between rs12146713 (NUAK1) and sulcal width measures, (b) widespread positive and negative associations between rs4843553 (near C16orf95) and sulcal width, depth and surface area measures, (c) widespread positive associations between rs11759026, containing CENPW, and all four sulcal measures, and (d) bilateral associations between an intergenic variant, rs2033939, and length, width, depth and surface area of the central sulci, precentral sulci, and posterior lateral fissures.
