Fig. 4: Stable disease patients show increased cytotoxic CD8s and B cells post-vaccination. | Nature Communications

Fig. 4: Stable disease patients show increased cytotoxic CD8s and B cells post-vaccination.

From: A phase I study of an adenoviral vector delivering a MUC1/CD40-ligand fusion protein in patients with advanced adenocarcinoma

Fig. 4

a Mass cytometry data were clustered by FlowSOM and analysed for clusters that differed pre and post-vaccination in patients with stable disease as defined by RECIST v.1.1. The phenotypes of these clusters are summarised in the heatmaps of marker expression. The median frequency of each cluster was represented by the size of the dots. b Manual gating validation of selected subsets in (a) Heatmap represents the scaled arcsin median expression of each marker. Mann–Whitney U tests (two-tailed) were performed to compare between groups (n = 6 patients). Error bars indicate SE of the mean. Some samples were excluded from supervised analyses due to insufficient cell numbers. Source data are provided as a Source Data file.

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