Fig. 6: The MN-CCPCA patch inhibits tumor recurrence by ion interference-enhanced repeatable 5-ALA-PDT.
From: Synthetic biology-instructed transdermal microneedle patch for traceable photodynamic therapy
a Schedule of the therapeutic process upon FL/PA duplex imaging navigation. b Individual tumor growth curves and c relative growth curves of A375 tumors in different treatment groups. d Average weight of A375 tumors at the end of the treatment period. All data represent the means ± SD from five biologically independent female A375 tumor-bearing mice, n = 5. Statistical significance was calculated with two-tailed Student’s t test. e Photographs of A375 tumors (n = 5) dissected from the mice on day 14 after exposure to different treatments. f HIF-1α-, H&E-, Ki67-, and TUNEL-stained sections from A375 tumor-bearing mice after various treatments indicated. Images are from five biologically independent tumors of 6-week-old female BALB/c-nude mice, n = 5. Scale bar = 100 μm. The symbols “+” indicate laser irradiation. Source data are provided as a Source data file.
