Fig. 3: DNA methylation changes in DNMT3A-depleted Caco-2 cells. | Nature Communications

Fig. 3: DNA methylation changes in DNMT3A-depleted Caco-2 cells.

From: DNA methyltransferase 3A controls intestinal epithelial barrier function and regeneration in the colon

Fig. 3

a Heatmaps of differentially methylated regions (DMRs) of WT, ΔDNMT3A, DNMT3A1, and DNMT3A2 cell lines (n = 4). Scaled gene expression/methylation intensity across all samples are plotted. b Bar plot indicating number of regions differentially methylated in genes rescued by DNMT3A1 and DNMT3A2 isoforms. c Correlation between gene expression and DNA methylation of up- (red) and downregulated (blue) rescued genes classified by the GO terms to which the genes belong. Top selected GO terms enriched in the rescued genes are shown. Each point represents a gene, and the size of the points is proportional to statistical significance (FDR) of the correlation with larger points being more significant.

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