Fig. 2: The binding of αNF to dAHR PAS-B.
From: Structural insight into the ligand binding mechanism of aryl hydrocarbon receptor
a Chemical structure of typical AHR ligands. b Binding of different AHR ligands to dAHR PAS-B detected by MST. Data are presented as mean values of two independent experiments. Source data are provided as a Source Data file. c Structure of αNF (red sticks) in complex with dAHR PAS-B. d The 2Fo-Fc omit map of αNF. The map is shown in gray mesh and contoured at 1.0 σ. e The binding of αNF in the dAHR PAS-B internal cavity. Residues shaping the αNF binding site are shown in sticks. The corresponding residues in mAHR PAS-B are shown in parentheses. H-bonds are indicated by dashed lines. f Structural comparison of apo dAHR PAS-B (green) and αNF-bound dAHR PAS-B (blue). The side chains of dAHR PAS-B M331 and I332 are shown in sticks. The corresponding mAHR residues M342 and I343 are indicated in parentheses.
