Fig. 5: Geometric mean neutralizing titers (GMT50) against WA-1 versus Omicron BA.1, BA.2, or BA.4/5.

a boosted vaccinated plasma with or without BA.1 COVID-19 and b unvaccinated pre-Omicron or BA.1 CCP. Geomeans (geometric standard deviation for error bars), for entire study groups with neutralization of WA-1 in filled circles with Omicron in empty circles with geomeans and fold reduction (FR) above data and number of studies above x axis. All geomeans are not statistically significant in difference by multiple comparisons in Tukey’s test. The percent of total samples within a study condition which neutralized Omicron graphed in increasing percentages on the left y axis with the number of total samples tested on the right y axis. c uninfected 3-dose vaccine neutralization of Omicron BA.1, BA.2, and BA.4/5; d post-COVID-19-BA.1/post-vaccine (Vax-CCP). Source data are provided as a Source Data file.