Fig. 4: Mechanism of H3R antagonism.
From: Structural basis for recognition of antihistamine drug by human histamine receptor
a Superpositions of the ligand-binding pockets of H3R–PF-03654746 (H3R in forest green, PF-03654746 in violet), H1R–Doxepin (PDB ID: 3RZE, H1R in gray, Doxepin in yellow), and H1R–Histamine (PDB ID: 7DFL, H1R in pink, Histamine in green) from the membrane view. Structural comparisons of the toggle switch (b), PIF motif (c), DRY motif (d), and NPxxY motif (e) with the same colors as a.
