Fig. 3: Trans- and cis-diagnostic risk variant enrichment at histone-acetylated marks on adult immune cells in the BLUEPRINT dataset.
a Bar plots show enrichment of genetic risk for each disorder at active promoters/enhancers (H3K27ac marks) in unstimulated, sorted immune cells. CHEERS was used to detect enrichment of risk loci at cell-type specific H3K27ac peaks (see Methods). P-values are reported from a discrete uniform distribution (one-sided tests). The dotted black line marks the nominal significance threshold, P < 0.05; the solid black line marks the Bonferroni-corrected significance threshold, PBonf < 0.05. Note differing x-axis scales. See Supplementary Fig. 5A for ADHD and bipolar disorder results (non-significant after Bonferroni correction). b Venn diagram shows counts of variant-peak overlaps shared between disorders and unique to each disorder (each peak is only counted once even if overlapping multiple variants). For an upset plot of peak overlaps across all disorders, see Supplementary Fig. 5B. TD terminally differentiated, NK natural killer, BMI body mass index.
