Fig. 1: Graphical outline of study design and cell counts and single-cell transcriptomics of peripheral blood mononuclear cells. | Nature Communications

Fig. 1: Graphical outline of study design and cell counts and single-cell transcriptomics of peripheral blood mononuclear cells.

From: Reprogramming of myeloid cells and their progenitors in patients with non-medullary thyroid carcinoma

Fig. 1

A Study Design Baseline Measurements: Bone marrow and Peripheral blood were collected from Thyroid carcinoma (TC) patients, Multinodular Goiter (MNG) patients and Healthy Controls (HC). Illustration created with BioRender.com. B Box plot of cell counts in whole blood. (HC n = 8, MNG n = 13, TC n = 12) Mean ± SEM. One-way ANOVA followed by Bonferroni post hoc correction. C UMAP projection of the 16,161 PBMC-derived single cells from 24 samples (HC n = 5, MNG n = 9, TC n = 10). All the major cell types were identified using canonical markers (Fig. S1A). D GO term enrichment analysis of differentially expressed genes in MNG and TC, compared to HC. Over-representation analysis on the significantly differentially expressed genes for each relevant comparison was used to determine significance. P values were measured using the hypergeometric distribution and adjusted using Benjamini-Hochberg correction. Source data are provided as a Source Data file.

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