Fig. 9: JAK1 degradation mediated by AIV PB2 affects virus replication in mammalian cells.
From: The influenza virus PB2 protein evades antiviral innate immunity by inhibiting JAK1/STAT signalling
a, b Immunoblots of A549 cells infected with rCZ, rCZM, rJY, or rJYM virus (left). The intensities of the bands on the immunoblots from three independent experiments were quantified and normalized with actin (right). c, d Growth curve of viruses in A549 (c) or DF-1 cells (d) infected with rCZ, rCZM, rJY, or rJYM at an MOI = 0.01 (n = 3 biologically independent samples). hpi, h post-infection. e The plaque morphology of MDCK cells infected with rCZ, rCZM, rJY, or rJYM virus. Data are presented as the mean ± SD. Statistical significance was determined by unpaired two-tailed Student’s t test. ns P > 0.05.
