Fig. 1: Schematic design of the hypoxia-responsive drug delivery system. | Nature Communications

Fig. 1: Schematic design of the hypoxia-responsive drug delivery system.

From: Lactose azocalixarene drug delivery system for the treatment of multidrug-resistant pseudomonas aeruginosa infected diabetic ulcer

Fig. 1

The supramolecular formulation Cip@LacAC4A can actively target the MDR PA infecting diabetic rat wound via the interactions of lactose and the surface glycoproteins of bacteria. Then azo groups respond quickly under hypoxic condition, which leads to the controlled release of antibiotic for bacterial infections. It can downregulate the expression of inflammatory factors, and accelerate the wound healing.

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