Fig. 1: UC-GENOME study design and molecular subtyping shows enrichment of Stroma-rich primary tumors in metastatic datasets. | Nature Communications

Fig. 1: UC-GENOME study design and molecular subtyping shows enrichment of Stroma-rich primary tumors in metastatic datasets.

From: Collaborative study from the Bladder Cancer Advocacy Network for the genomic analysis of metastatic urothelial cancer

Fig. 1

a Consort diagram showing enrollment and sample banking along with downstream sample attrition and available data. b Subtype calls were made on the UC Genome data for the consensus subtypes. Log2 median centered mRNA expression for selected bladder specific markers were sorted by the Consensus subtype call. c Gender distribution by subtype. Y-axis represents the number of patients. The frequency of gender within each subtype is shown within their respective portion of the barplot. d Subtype distribution across non-metastatic (TCGA/Kamoun) and metastatic (IMvigor210/UC-GENOME) cohorts. e Comparison of Stroma-rich subtypes between all the cohorts. For d and e the number of samples within each group is shown within their respective portion of the barplot, with the Mantel-Haenszel χ2 p-value is indicated above. f Heatmap visualization of the χ2 p-values comparing the proportion of Stroma-rich tumors within each cohort. Source data are provided as a Source Data file.

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