Fig. 4: Ba/Sq tumors are T cell inflamed but luminal tumors are enriched in memory B cells and plasma cells. | Nature Communications

Fig. 4: Ba/Sq tumors are T cell inflamed but luminal tumors are enriched in memory B cells and plasma cells.

From: Collaborative study from the Bladder Cancer Advocacy Network for the genomic analysis of metastatic urothelial cancer

Fig. 4

a Tumor samples (n = 176 samples) were clustered by samples and Immune Gene Signature (IGS) z-scores. IGS were clustered within their respective immune group (right of dashed line). Boxplots for signatures related to ICI response and b T-cells or c stroma/EMT were plotted by z-score and consensus subtype (n = 176 samples). d TCR family abundance and evenness were estimated from RNA using MiXCR and plotted by Consensus subtype (n = 153 samples). e Selected CIBESORTx cell types that were significantly associated with either e UNC subtypes or f Consensus subtypes were plotted by boxplot (n = 176). Wilcoxon p-values are shown above plot. All boxplots are shown with boxes representing the IQR and midline at the median. Error bars represent Q1/Q3  ±  1.5 × IQR. Source data are provided as a Source Data file.

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