Fig. 2: Structural-variant signatures in ESCC. | Nature Communications

Fig. 2: Structural-variant signatures in ESCC.

From: Characterization of somatic structural variations in 528 Chinese individuals with Esophageal squamous cell carcinoma

Fig. 2

a Left panel: Size distribution of tandem duplication, deletion, and inversion. Pie chart shows the frequencies of different SV signatures. Right panel: Bar plot shows the frequencies of different mechanisms of these signatures. The stars represent a significant difference of proportion of FoSTes/MMBIR between two groups. b Bar plot shows the enrichment of a high proportion of BRCAness signature in ESCCs with TDP. c Box plot shows the high TD-c1 proportion in ESCCs with BRCA1 mutation. n = 528 biologically independent pairs of samples. On the boxplots the horizontal line indicates the median, the box indicates the first to third quartile and whiskers indicate 1.5× the interquartile range. d Bar plot shows the enrichment of BRCA1 mutation in ESCCs with TDP and high TD-c1 proportion. Statistical analysis is performed with a student t- test. *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001. Source data are provided as a Source Data file.

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