Fig. 4: Complex rearrangements that prevalent in ESCCs.

a An example illustrates the method of how to construct potential complex rearrangement. b A diagram of three types of complex rearrangement. The number for each complex rearrangement is marked. The pie chart shows the type of TSI near to start or end breakpoint of complex rearrangement. The black solid lines represent the copy number states of the target region, whereas structural variations are shown as colored dotted lines (brown: breakpoint strand “--”; green: breakpoint strand “++”; purple: translocation) linking two segments. Source data are provided as a Source Data file.