Fig. 5: Landscape of TSI fold-back inversions in ESCC.

a An example of TSI fold-back inversion in ESCC. b Bar plot shows distribution of fold-back inversion on each chromosome. Pie chart shows the frequencies of three types of TSI fold-back inversion. c Kaplan-Meier survival curves shows the survival outcomes of TSI fold-back inversion in ESCC. Statistical analysis is performed with Log-rank test. d Kaplan-Meier survival curves shows complex fold-back have a similar worse prognosis in validation data. Statistical analysis is performed with Log-rank test. e Density plot shows association between fold-back inversion and centromere. f A specific example shows fold-back inversion be close to centromere not only in physical distance but also in actual distance. g Bar plot shows spectrums of fold-back inversions amplified genes recurrently. Bottom panel shows an example that CCND1 and MMPs on chromosome 11 were amplified by fold-back inversions synchronously. Source data are provided as a Source Data file.