Fig. 6: Substrate scope of alkenes for allylic coupling reactions and for the synthesis of β-lactams.
From: Divergent regioselective Heck-type reaction of unactivated alkenes and N-fluoro-sulfonamides
Conditions B: 1 (0.20 mmol), 2a (0.50 mmol), Cu(TFA)2·H2O (0.02 mmol), Zn(OAc)2 (0.08 mmol), and TFA (0.40 mmol) in benzene (2.0 mL) at 90 °C for 4 h. Conditions C: 1 (0.20 mmol), 2a (0.50 mmol), and Cu(TFA)2·H2O (0.02 mmol) in dioxane (3.0 mL) at 90 °C for 3 h. Isolated yields are shown. E/Z is >20:1 if not stated otherwise. TFA trifluoroacetic acid. aThe yield was recorded after a Boc-protection of the crude secondary amine product.
