Fig. 2: Reconstruction of shattered chromosomes. | Nature Communications

Fig. 2: Reconstruction of shattered chromosomes.

From: Integration of Hi-C with short and long-read genome sequencing reveals the structure of germline rearranged genomes

Fig. 2

a Overlay of curated SV calls from Illumina GS (pink squares) and PacBio GS (black squares) for a cis Hi-C map as well as for b a trans Hi-C map. c Circos plots for 11 samples showing all curated large-scale novel adjacencies. d Reconstruction graph and derivative chromosomes for CP4. The chromosome reconstruction strategy comprises several steps starting with (i) the placement of all curated breakpoints to generate chromosomal fragments, (ii) connecting chromosomal fragments according to SV calls, (iii) tracing all possible paths in the fragment graph to obtain derivative chromosomes. e Reconstruction graph and derivative chromosomes for CT4. The last column shows leftover singletons. Note, small fragments and telomeric ends are shown enlarged.

Back to article page