Fig. 3: Analysis of the 3D chromatin structure around breakpoints. | Nature Communications

Fig. 3: Analysis of the 3D chromatin structure around breakpoints.

From: Integration of Hi-C with short and long-read genome sequencing reveals the structure of germline rearranged genomes

Fig. 3

For selected genomic features, a horizontal line indicates the expected value, which is derived from the genome-wide fraction of the corresponding feature. a Number of novel adjacencies with breakpoints located in the same TAD, in neighboring TADs, spanning at least one TAD and on different chromosomes, respectively. b Percentage of breakpoints locating in TAD boundary regions (±50 kb). The black line indicates the percentage expected by chance. N is the number of novel adjacencies evaluated. c Fraction of compartment type of the breakpoint location for individual samples. The expected line shows here the genomic fraction of the B-compartment. d Number and type of compartment fusions induced by the large-scale novel adjacencies. e Fraction of breakpoints located in LADs. The black line indicates the percentage expected by chance. f Number and type of LAD/Non-LAD fusions.

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