Fig. 7: A model illustrating the function of EIF4E and ALDH1B1 in regulating 4HNE-mediated ferroptosis.
From: A noncanonical function of EIF4E limits ALDH1B1 activity and increases susceptibility to ferroptosis
EIF4E promotes ferroptosis by directly blocking ALDH1B1, thereby promoting the accumulation of toxic 4HNE and subsequent NOX1-dependent lipid peroxidation.
