Fig. 3: The CcmABCD complex undergoes conformational changes upon the binding of substrates.
From: Structures of the CcmABCD heme release complex at multiple states
a Closed NBD conformation of CcmABCD bound with two phosphates. b Open NBD conformation of ligand-free CcmABCD. c Closed NBD conformation of CcmABCD bound with two AMP-PNPs. d Closed NBD conformation of CcmABCD bound with two ATPs and one heme. e Semi-open NBD conformation of CcmABCD bound with one ATP and one heme. The distance between the two Ala190s (shown in black spheres) on each NBD is indicated by yellow dash line and labeled in red font.
