Fig. 6: Cartoon representation of a proposed model for selective activation of IR.
From: Functional selectivity of insulin receptor revealed by aptamer-trapped receptor structures
a Apo state with basal activity; b Two m-pY1150 states, arrowhead-shaped IR2xA62 (left) and the tilted T-shaped IRA62+Ins (right), that selectively activate the metabolic signaling. A62 and insulin are shown in a purple circle and pink triangle, respectively. The primary insulin binding site in the arrowhead conformation can be exposed by the rigid body rotation of the apo-IR in a. The site-1+insulin module is lifted up toward FnIII-1′ (right). Initial insulin binds to site-1 and site-2′; c In the IRA43+Ins structure, L1′ translocation toward FnIII-2 stalks for full activation. A43 is shown in the cyan square.
