Fig. 1: Perivascular clusters of OPCs with impaired differentiation in cerebral hypoperfusion. | Nature Communications

Fig. 1: Perivascular clusters of OPCs with impaired differentiation in cerebral hypoperfusion.

From: Vascular endothelium deploys caveolin-1 to regulate oligodendrogenesis after chronic cerebral ischemia in mice

Fig. 1

a–c Representative confocal images and quantitative analyses of cluster number and size of PDGFRα+Olig2+ cells on CD31+ blood vessels (n = 5 mice/group). Scale bar, 10 μm. d Ultrastructural images displaying the interactions between Olig2 immunogold labeled cells (pseudocolor-green) and the vessel (pseudocolor-red). Magnified regions showing the oligodendroglial cell process attached to the vessel in the right panel (n = 5 mice/group). Scale bar, 2 μm. e–g Representative immunofluorescence images and quantifications showing the changes in the percentage of BCAS1+ or ENPP6+ newly formed immature oligodendrocytes (n = 5 mice/group). h, i Representative images and quantifications showing the changes in CC1+Olig2+ mature oligodendrocytes (n = 5 mice/group). Scale bar, 10 μm. All data are presented as the mean ± SD. The data were compared by one-way ANOVA with Tukey post hoc test. BV blood vessel, O oligodendroglial cells. Source data are provided as a Source Data file.

Back to article page