Fig. 10: PEI-antagomir ameliorates OPC perivascular clustering and promotes remyelination via Cav-1. | Nature Communications

Fig. 10: PEI-antagomir ameliorates OPC perivascular clustering and promotes remyelination via Cav-1.

From: Vascular endothelium deploys caveolin-1 to regulate oligodendrogenesis after chronic cerebral ischemia in mice

Fig. 10

a Representative immunofluorescent images and reconstruction showing the attenuation in perivascular Olig2+ cell clusters in wild type and Cav-1−/− mice treated with antagomir (n = 5 mice/group). Scale bar, 20 μm. b, c Quantitative analyses of cluster number and size around CD31+ vessels (n = 5 mice/group). d Perivascular clustering of PDGFRα+ OPCs in mice of 2 genotypes subjected to N.C. or antagomir (n = 5 mice/group). Scale bar, 20 μm. e, f Quantifications of the cluster number and size (n = 5 mice/group). g–i Representative staining of newly-formed pre-myelinating BCAS1+ or ENPP6+ cells (n = 5 mice/group). Scale bar, 20 μm. All data are presented as the mean ± SD. The data were compared by one-way ANOVA with Tukey post hoc test. Source data are provided as a Source Data file.

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