Fig. 1: Comparison of dMRI-FA to corresponding myelin histology and MTR MRI data obtained from the same tissue in the right hemisphere of marmoset monkey case P.
From: Diffusion MRI anisotropy in the cerebral cortex is determined by unmyelinated tissue features
a Sagittal sections of dMRI-FA (top), Myelin histology (center), and MTR MRI (bottom). The spatial variation of dMRI-FA in vertical (laminar) and horizontal direction showed minimal correspondence with the pattern of myelin intensity, but the variation of the MTR MRI closely mirrored the myelin variation. In some regions of high myelination (dark colour in histology), the dMRI-FA was high (red arrow) whereas in others it was low (blue arrow). b Normalized average laminar profiles of FA, MTR and myelin intensity through the cortical thickness from roughly 100 μm above the white gray boundary (WGB) to roughly 100 μm below the pial surface (PIA) in the brain’s left hemisphere, derived from cortical parcellation (see Methods, Fig. 3). c Histogram of correlation coefficients between MRI variables and histological myelin intensity over the nine sections of coronal histology used in this study. MTR MRI shows much higher correspondence with myelin intensity than dMRI-FA does. Source data are provided as a source data file.
