Fig. 5: Average laminar profiles of FA, Nissl-HA, and myelin-HA across all parcels and the results of a spatial randomization condition to test the regional specificity of parcel-wise histology to MRI correlations.
From: Diffusion MRI anisotropy in the cerebral cortex is determined by unmyelinated tissue features
The results show Nissl-HA more closely matches the laminar profile of dMRI-FA, and is more sensitive to shuffling of horizontal MRI locations. a Normalized laminar profiles of dMRI-FA, Myelin-HA, and Nissl-HA through the cortical thickness, from roughly 100 μm above the white/gray matter boundary (WGB) to roughly 100 μm below the pial surface (PIA), computed from the average of all columnar parcels (see Methods, Fig. 3). Bars indicate standard deviation. b The mean parcel correlation coefficients between MRI and histology variables from matched locations (see Fig. 4), and when the cortical parcels of the histology parameters and those of the dMRI-FA are shuffled between random horizontal locations. MI myelin intensity, N-HA Nissl-HA, M-HA myelin-HA. Bars indicate standard error. The star indicates significance under a two tailed paired t-test, p < 10−10. ρ indicates mean Pearson correlation coefficient. Each parcel is one of n = 393 biologically independent samples from the marmoset cortex, spanning 18 distinct histological sections. Source data are provided as a source data file.
