Fig. 4: ACAs differently detected in non-progressors and progressors compared to controls.
From: Use of a glycomics array to establish the anti-carbohydrate antibody repertoire in type 1 diabetes
a Radar charts showing –log10(p value) with blue representing association with progression (blue dots and shaded area) and red representing association with non-progressors (red dots and shaded area). The gray shadowed area represents non-significances (p > 0.05). Aminoglycoside structures drawn using ChemDraw version 19.1.0.8. b Boxplot of ACA levels against gentamicin for fucosyltransferase-2 (FUT2) (rs601338) genotypes G/G (N = 41), A/A (N = 39), and G/A (N = 84). Differences between the FUT2 genotype groups were evaluated by Tukey’s test accounting for multiple testing with Benjamini-Hochberg method, horizontal lines on the box represent the 25th, 50th and 75th percentile, the whiskers represent maximum and minimum values of anti-gentamicin IgG values. All p values were two-sided and a p < 0.05 was considered significant. c Directed acyclic graph of report associations related to FUT2 and T1D51,52, FUT2 and neonatal sepsis48, prematurity and T1D58, prematurity and neonatal sepsis56, neonatal sepsis and gentamicin56, and our reports of FUT2 association with ACAs against gentamicin and of ACAs against gentamicin and T1D. Created with BioRender.com. spp.: species. Source data are provided as a Source Data file.
