Fig. 7: Metabolite signatures of the childhood exposome and dietary sources.
From: Multi-omics signatures of the human early life exposome
A Cluster childhood#3 includes the significant associations between fish and several contaminants (As, Hg, PFOS) and serum metabolites (mainly glycerophospholipids). B Cluster childhood#6 includes the significant associations between diet (vegetables, fruit, cereals) and organophosphate (OP) pesticides with urinary metabolites. For A, B, nodes of the network are depicted with a different colour/shape depending if they are exposures or features of a particular molecular layer (see legend in the figure). An exposure and a molecular feature were connected with an edge if their association was statistically significant (blue if positively and red if negatively). C Tripartite plots based on the presence of associations between metabolites-exposure in HELIX samples (on the left) and metabolites-dietary intake based on the ExposomeExplorer database (http://exposome-explorer.iarc.fr/)36 (on the right). Serum and urinary metabolites are shown in red and yellow, respectively, and exposures in blue (fish and contaminants), red (organochlorine chemicals) or green (non-persistent chemicals and diet) according to the cluster they belong to.
