Fig. 2: Trans-ethnic meta-analyses across all cohorts identified 20 genome-wide significant loci. | Nature Communications

Fig. 2: Trans-ethnic meta-analyses across all cohorts identified 20 genome-wide significant loci.

From: Genetic regulation of serum IgA levels and susceptibility to common immune, infectious, kidney, and cardio-metabolic traits

Fig. 2

a Manhattan plot depicting a total of 11 novel loci (red) as well as 9 known loci (purple) identified in the meta-analysis; the dotted horizontal line indicates a genome-wide significance threshold (P = 5 × 10−8); the y-axis depicts -log10(P-value) for the fixed effects meta-analysis (two-sided, unadjusted), and is truncated to accommodate large peak at RUNX3 locus. b Correlation between average frequency of the independently significant alleles associated with higher IgA levels (x-axis) and their age and sex adjusted effect size (y-axis, standardized betas). c Pleiotropic effects of the IgA GWAS loci; GWAS loci for IgA levels are in green; other traits are in purple; arrows represent allelic associations that are identical to or in tight LD (r2 > 0.5) with the IgA effect alleles; concordant effects indicated in red; opposed effects in blue.

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