Fig. 5: Colocalization and Mendelian randomization analyses based on GWAS for serum IgA levels, IgA nephropathy and tonsillectomy. | Nature Communications

Fig. 5: Colocalization and Mendelian randomization analyses based on GWAS for serum IgA levels, IgA nephropathy and tonsillectomy.

From: Genetic regulation of serum IgA levels and susceptibility to common immune, infectious, kidney, and cardio-metabolic traits

Fig. 5

a Regional plot of the HORMAD2/LIF locus for IgA levels (without the deCODE-Lund cohort, top panel), IgA nephropathy (middle panel), and tonsillectomy (lower panel). The two-sided unadjusted P-value corresponds to the fixed effects GWAS meta-analysis. b Co-localization analysis of HORMAD2/LIF locus across the three traits; PP4 is the posterior probability of co-localization. c Mendelian randomization analysis using IgA level (GWAS N = 41,263) as an exposure, IgA nephropathy (GWAS N = 38,897) as an outcome, and co-localizing loci as instruments. The error bars correspond to 95% confidence intervals for the effect size. The x and y axis represent effect sizes of the genetic variants associated with the exposure and outcome, respectively. P-value corresponds to the two-sided inverse variance weighted (IVW) Mendelian Randomization test.

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