Fig. 2: Preparation and NIR-induced disintegration of NGs@TMZ/ICG.

a Schematic illustration of the synthesis of the nanogels and their NIR-induced disintegration. b, c Size distribution (b) and zeta potential (c) of the corresponding nanoparticles measured by DLS (n = 3 independent experiments). Data are presented as mean ± SD. d TEM images of the NGs@TMZ/ICG before and after NIR irradiation (808 nm, 0.5 W cm⁻², 5 min). e Particle sizes of NGs@TMZ/ICG before and after NIR irradiation (808 nm, 0.5 W cm⁻², 5 min) measured by DLS. f Photographs and the florescence images (FL) of the RB-containing nanogels upon light irradiation for different time (520 nm, 5 mW cm⁻²). g Raman spectra of NGs@TMZ/ICG after exposure to NIR irradiation for different time (808 nm, 0.5 W cm⁻²). h Change in the normalized Raman intensity of C=C bonds (1520 cm⁻¹) and C ≡ C bonds (2120 cm⁻¹) as a function of sunlight irradiation time.