Fig. 4: Simulations of populations under bottlenecks and admixture. | Nature Communications

Fig. 4: Simulations of populations under bottlenecks and admixture.

From: Repeated out-of-Africa expansions of Helicobacter pylori driven by replacement of deleterious mutations

Fig. 4

a Within population dN/dS and b dN/dS calculated to the ancestor measured at generation 8000. Semi opaque points show pairwise distances; solid points indicate population means. c Population average fitness shown during the generations of the simulation, with bottleneck starting at generation 5000 (horizontal line) and admixture at generation 8000 (arrow). d Proportion of bottleneck and non-bottleneck ancestry in the bottleneck population, for the generations after the beginning of admixture. Sites with unknown ancestry are shown in gray. Each arrow corresponds to the migration of one strain. e Ancestry painting in a sample of genomes from the bottleneck population, in the generations subsequent to admixture. Only the first 20 kb of each genome is shown. f Average bottleneck population ancestry, at generation 8300 plotted against mutation score (frequency in the non-bottleneck population minus the frequency in the bottleneck population before the admixture begins). Error bars show the standard error on the mean (for each bin, from −1 to 1, the sample size is 1369, 344, 453, 639, 1264, 914, 666, 381, 241, 251, 1839). Source data are provided in the github repository https://github.com/EliseTourrette/Hpylori/tree/main/HpEurope (DOI: 10.5281/zenodo.7130003).

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