Fig. 4: Phagocyte depletion reduces arthritis severity and bone erosion in IL1rn−/− mice.
From: mTORC1 links pathology in experimental models of Still’s disease and macrophage activation syndrome
a Peripheral blood monocyte count, (b) spleen size, (c) ankle joint thickness, (d) composite arthritis score, (e) bone erosion score (micro-CT) and (f) representative depiction of joint histology in IL1rn−/− mice treated with PBS-liposomes (n = 6) or clodronate-liposomes (n = 5) for 6 weeks. Data in (a, b, d, e, f) were pooled from 2 independent experiments. Mice were 6 weeks old for experiments in (a–f). Statistical analyses (all two-sided): Mann–Whitney U test (a, b, e); Student’s t test (c, d). *p < 0.05, **p < 0.01. Median and error bars representing interquartile range are displayed in (a, b, e). Mean and error bars representing standard errors are displayed in (c, d). Source data are provided as a Source Data file.
