Fig. 5: Correlation of testosterone and cytokine/chemokine levels in men infected with H7N9 influenza.
From: H7N9 avian influenza virus infection in men is associated with testosterone depletion
a–g Shown is the observed regression between testosterone and cytokine/chemokine levels in H7N9 IAV-infected males. Natural logarithm transformed (Ln) testosterone expression levels measured in the sera from H7N9 males were plotted over the Ln transformed cytokine/chemokines levels. a–e Overall regression of testosterone with cytokines IL-6 (interleukin 6; a), IL-10 (interleukin 10; b), IL-15 (interleukin 15; c), IL-1RA (interleukin 1 receptor antagonist; d) and IL-1α (interleukin 1 alpha; e) observed from H7N9 younger males without interaction between deaths and survivors (18–49 yrs survival/death: n = 18/15); f, g Observed overall regression of testosterone with cytokines IL-6 (interleukin 6; f) and IL-10 (interleukin 10; g) in H7N9 older males without interaction between deaths and survivors (≥50 yrs survival/death: n = 27/11). a–g The best-fit line with 95% confidence intervals of the overall regression is shown in each figure. The centre of the error distribution is the regression line. Two-tailed linear regression was performed. Adjustment for multiple hypotheses was not necessary due to the explorative nature of the study. A hollow blue circle represents survival, and a solid blue circle represents death. R squared values are shown in the figures. Source data are provided as a Source data file.
