Fig. 4: Clonal expansion of CD4+ T cell subsets in ALS.
From: T cell responses at diagnosis of amyotrophic lateral sclerosis predict disease progression
t-SNE plots of 10X scRNA-seq data showing T cell subsets and contour plots outlining TCR expansions identified using 10X VDJ scRNA-seq in five ALS patients, two non-inflammatory controls, and two normal pressure hydrocephalus (NPH) controls individuals (A). Quantification of TCR expansion from 10X VDJ scRNA-seq from ALS patients and controls (B) with significance displayed in ascending order (C). For each cell type, p values were calculated using Pearson’s Chi-squared test and Monte Carlo simulation with 2000 replicates.
