Table 3 Hazard ratios (HR) and their 95% confidence intervals (CI) of death (or use of invasive ventilation) in relation to the frequency of T cell subsets in blood or cerebrospinal fluid (CSF), after adjustment for age at diagnosis, sex, site of onset, diagnostic delay, disease progression rate at diagnosis, body mass index (BMI), and the time difference between measurement of BMI and blood sampling
From: T cell responses at diagnosis of amyotrophic lateral sclerosis predict disease progression
Cell population out of live cells (%) | Tertile | Blood | CSF | |||
|---|---|---|---|---|---|---|
No. of patients (outcomes) | HR (95% CI) | No. of patients (outcomes) | HR (95% CI) | |||
CD3+ | Low | 26 (12) | Ref | 27 (15) | Ref | |
Medium | 26 (16) | 2.47 (1.11–5.52) | 27 (17) | 2.21 (1.01–4.82) | ||
High | 26 (16) | 2.49 (1.03–6.03) | 26 (14) | 1.24 (0.54–2.82) | ||
CD4+ | Low | 26 (13) | Ref | 27 (14) | Ref | |
Medium | 26 (15) | 1.82 (0.81–4.06) | 27 (16) | 1.79 (0.82–3.93) | ||
High | 26 (16) | 2.29 (1.04–5.04) | 26 (16) | 3.04 (1.24–7.46) | ||
CD8+ | Low | 22 (13) | Ref | 23 (10) | Ref | |
Medium | 22 (13) | 1.04 (0.44–2.46) | 22 (16) | 1.22 (0.47–3.15) | ||
High | 22 (09) | 0.81 (0.32–2.06) | 22 (11) | 0.78 (0.30–2.06) | ||
Teff | Low | 26 (13) | Ref | 27 (14) | Ref | |
Medium | 26 (14) | 1.61 (0.72–3.62) | 26 (15) | 1.68 (0.75–3.77) | ||
High | 25 (17) | 2.43 (1.10–5.37) | 26 (17) | 3.18 (1.33–7.64) | ||
Treg | Low | 26 (12) | Ref | 27 (17) | Ref | |
Medium | 26 (14) | 1.44 (0.64–3.23) | 26 (13) | 0.96 (0.44–2.08) | ||
High | 25 (18) | 1.39 (0.64–3.00) | 26 (16) | 0.87 (0.41–1.86) | ||
aTreg | Low | 26 (15) | Ref | |||
Medium | 25 (12) | 0.40 (0.17–0.92) | ||||
High | 25 (17) | 0.76 (0.37–1.59) | ||||
rTreg | Low | 26 (13) | Ref | |||
Medium | 26 (16) | 1.65 (0.76–3.60) | ||||
High | 25 (15) | 1.59 (0.69–3.66) | ||||
aTreg/rTreg (ratio) | Low | 26 (14) | Ref | |||
Medium | 25 (16) | 1.06 (0.46–2.43) | ||||
High | 25 (14) | 0.56 (0.24–1.31) | ||||
