Fig. 5: Prestin-prestin communication through lipids.
a Initial system setup with two contracted prestin dimers at 90° [90°, 90°]. The center of mass of each dimer is restrained, but they are allowed to rotate freely. Orientation of the two prestin dimers are denoted as θ1 and θ2, respectively. b Time series of θ1 (orange) and θ2 (green) during the 40 μs simulation. The radial direction in the polar plot represents the time from 0 to 40 μs. See also Supplementary Movie 2. Source data are provided as a Source Data file. c Free energy landscape in θ1/θ2 space, constructed from the last 30 μs of the trajectory. The landscape consists of three main minima. The pink and magenta circles correspond to [45°, 45°] and [135°, 135°] prestin-prestin configurations, respectively, also highlighted in b by diagonal bars.
