Fig. 7: Accumulation of POPI and CHOL around prestin.
a Heatmaps representing the distribution of POPI and CHOL over the last 5 ÎĽs of the quad-prestin trajectory in the contracted conformation. Both POPI and CHOL cluster closely to the core and gate domains of prestin. The region in between the two protomers contains two distinct CHOL binding sites but remains free of POPI during the simulation. b Comparison of cryo-EM and MD CHOL. The trajectory of one of the CHOL molecules in between the two protomers during the last 10 ÎĽs of the simulation is shown in varying colors representing the time (scale bar). Only the hydroxy bead is shown for each frame. The cryo-EM CHOL models are shown in yellow. Source data are provided as a Source Data file.
