Table 2 Vaccine effectiveness measures

From: Effectiveness of a third BNT162b2 mRNA COVID-19 vaccination during pregnancy: a national observational study in Israel

 

Delta period

Omicron period

 

Hospitalization

Significant disease

Severe disease

Hospitalization

Significant disease

Severe disease

 

HR

1-HR (95% CI)

HR

1-HR (95% CI)

HR

1-HR (95% CI)

HR

1-HR (95% CI)

HR

1-HR (95% CI)

HR

1-HR (95% CI)

3rd vs. 2nd vaccine group

0.08 (0.04–0.17)

92% (83–96)

0.15ab (0.01–1.83)

0 vs. 4

0.17ab (0.01–2.40)

0 vs. 3

0.52 (0.43–0.63)

48% (37–57)

0.08 (0.01–0.74)

92% (26–99)

0.41ab (0.02–6.68)

0 vs. 1

2nd dose vs. unvaccinated group

0.39 (0.31–0.49)

61% (51–69)

0.03 (0.01–0.08)

97% (92–99)

0.04 (0.01–0.14)

96% (86–99)

1.12 (0.92–1.36)

[−12%] ([−36]−8)

0.49 (0.16–1.47)

51%([−47]−84)

0.17 (0.02–1.47)

83% ([−47]−98)

3rd dose vs. unvaccinated group

0.03 (0.01–0.05)

97% (95–99)

0.01a (0.00–0.07)

99% (93–100) 0 vs. 108

0.02 a (0.00–0.11)

99% (89–100) 0 vs. 64

0.57 (0.47–0.69)

43% (31–53)

0.03 (0.00–0.28)

97% (72–100)

0.06a (0.01–0.57)

94% (43–99) 0 vs. 5

  1. HR of COVID-19 hospitalization degree for vaccinated group vs. unvaccinated group and between the vaccinated groups, in two study periods [Delta period- 1 August 2021–1 December 2021; Omicron period- 15 December 2021–22 March 2022]. The study period populations were 82,659 and 33,303 in each of the two periods, respectively. In each study period, 28,213 and 714 individuals were first included in the 2-dose group and then re-recruited to the 3-dose group.
  2. HR calculated using Cox proportional-hazards regression model with time-dependent covariates controlling for maternal age, parity and days of follow-up.
  3. Outcomes definitions: hospitalization with SARS-CoV-2 infection; significant disease (e.g., COVID-19-related pneumonia associated with COVID-19 justifying hospitalization), and severe disease (e.g., resting respiratory rate >30 breaths per minute, O2 saturation on room air <94%, etc.).
  4. aA single case was imputed to allow estimations of HR. Estimation is based on the mean of 1000 simulations.
  5. bEstimates (1-HR) were only calculated for cells with 5 events or more, otherwise, raw counts are reported.