Fig. 5: PELP1’s solvent-exposed LxxLL motifs are incompatible with steroid receptor binding.
From: Cryo-EM reveals the architecture of the PELP1-WDR18 molecular scaffold
a Schematic representation of PELP1’s Rix1 domain with localization of LxxLL and PxxP motifs. Motifs illustrated in model views are noted below the schematic (solvent motif labels colored blue). b Model view of a single PELP1 Rix1 domain protomer with solvent-exposed LxxLL motifs colored magenta. c, d, e Individual zooms of each solvent LxxLL motif with residue positions displayed. Solvent face is illustrated in each panel with dashed line for spatial orientation of the motifs. The invariant leucine residues required for AF-2 binding of SRs are buried away from the solvent face, rendering them inaccessible for SR binding.
