Fig. 2: Scope of enantioselective synthesis of N-benzyl and N-allylic indoles enabled by Ni-catalyzed C(sp3)-C(sp2) coupling reactions. | Nature Communications

Fig. 2: Scope of enantioselective synthesis of N-benzyl and N-allylic indoles enabled by Ni-catalyzed C(sp3)-C(sp2) coupling reactions.

From: Enantioselective synthesis of N-alkylindoles enabled by nickel-catalyzed C-C coupling

Fig. 2

Conditions: aAll reactions were carried out with NiI2•xH2O (10 mol%), ligand L*1 (15 mol%), 1 (0.40 mmol), 2 (0.80 mmol), (OEt)2MeSiH (0.48 mmol), KF (0.60 mmol) and DME/DCE (3:1, 2.0 mL) at room temperature for 20 h; bDME as solvent, (OEt)2MeSiH (0.72 mmol), KF (0.88 mmol), 48 h.

Back to article page